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| ELASTICA™ - SCIENTIST / INVENTION |
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| "The pioneer of Anti-Aging." |
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Department of Biochemistry
Loma Linda Unviversity School of Medicine |
| Lawrence B. Sandberg, PhD |
| Dr. Sandberg received his MD degree at the University of Illinois and his PhD at the University of Oregon. During his PhD, Dr. Sandberg studied connective tissue structure and metabolism with special emphasis on elastic tissues under the guidance of R. Jones, PhD. After receiving his PhD, Dr. Sandberg did a postdoctoral fellowship with Bill Dreyer, PhD, and Allan Hodges, PhD, at the California Institute of Technology in Pasadena, California, where he studied protein structure. Since coming to Loma Linda, his research has focused on elastin and connective tissue structure and metabolism. |
| Dr. Sandberg's research interests continue to be in the field of connective tissue biochemistry with a special emphasis on elastic tissues. These fields are important because of the heavy involvement of connective tissues in such diseases as coronary artery disease, pulmonary emphysema and skin aging. |
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Gray, W.R., Sandberg, L.B., Foster, J.A. 1973. Molecular model for elastin structure and function. Nature 246:461-466. |
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Sandberg, L.B., Soskel, N.T., Leslie, J.G. 1981. Elastin structure, biosynthesis, and relation to disease states. N Engl J Med 304:566-579. |
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Gibson, M.A., Hatzinikolas, G., Kumaratilake, J.S., Sandberg, L.B., Nicholl, J.K., Sutherland, G.R., Cleary, E.G. 1996. Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25). J Biolog Chem 271:1096- 1103. |
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Hieber, A.D., Corcino, D., Motosue, J., Sandberg, L.B., Roos, P.J., Yeh Yu, S., Csiszar, K., Kagan, H.M., Boyd, C.D., Bryant-Greenwood, G.D. 1997. Detection of elastin in the human fetal membranes: Proposed molecular basis for elasticity. Placenta 18:301-312. |
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The discovery of tropoelastin (the soluble precursor of elastin fibres). |
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The elucidation of the role of fibronectin in malnutrition. |
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The definition of the structures and roles in elastin synthesis of several microfibrillar proteins. |
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Medical Missionary to Nigeria 1960-1963 |
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Medical Missionary to Swaziland, South Africa 1977-1978 |
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Fibronectin study on malnourished children Phase 1, 1985 |
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Fibronectin study Phase 2, 1986-1988 |
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Publication 2 peer-reviewed papers on fibronectin administration to malnourished Liberian children |
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Formation of non-profit Lamb Orphanage, USA Inc 1989 |
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AIDS prevention seminars in Madagascar, southeast coast of Africa 1997 |
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AIDS prevention seminars Swaziland and Madagascar 1998 & 2000 |
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Medical mission trip to Swaziland orphans 2004 |
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Medical mission trip to Bulembu project and Swaziland Orphanages with a team of 18 people, 2006 |
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Medical mission trip to Ethiopia with a team of 8 people 2008 |
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| The invention of HEP (Hydrophilic Elastin Peptides) is directed to a formulation or composition which is used to enhance the softness, elastin, or appearance of tissue by increasing the endogenous elastin production. The present invention relates to compositions which are particularly suitable as therapeutics, pharmaceutics, and/or cosmetics. The compositions of the present invention preferably include a peptide or peptide-like compound which simulate the effect of elastin. Preferably, compounds of the present invention are substantially homologous or analogous with a portion of mammalian elastin, even more preferably with fragments of elastin endogenous to the tissue of the mammal being treated. It is preferable that the peptide or peptide-like compound(s) of the present invention are i:at a therapeutically effective concentration and/or are an active ingredient of a pharmaceutic, therapeutic and/or cosmetic composition. The peptide or peptide-like compound(s) of the present invention appear to aid the elasticity and/or turgor of the skin. Another aspect of the present invention is a method of administering the compositions of the present invention to achieve a therapeutic, pharmaceutic, or cosmetic effect. |
| Specifically, the present invention of HEP is directed to a composition formulated from the products of thermolysin digestion which are filtered through a 10,000 molecular weight cutoff device, which may be dried to have a formulation which contains 90% or greater of peptides having a molecular weight lower than 10,000 Da. This formulation is preferably applied to human skin in a cosmetic or therapeutic formulation and results in enhanced elasticity of the skin. For a complete description click here. |
| Consumers are increasingly seeking "anti-aging" products that treat wrinkling, creasing and furrowing of the skin. The advent of costly and painful cosmetic injections for treating expression lines of the face has heightened interest in finding topical alternatives that are effective and non-invasive. |
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